1,2-Dichloroethane → HCID 86594422, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-isopropylamino-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid (127 mg), N,O-dimethylhydroxylamine hydrochloride (41 mg), 1-hydroxy-7-azabenzotriazole (57 mg), and EDC (81 mg) in DMF (2.0 mL) was stirred at 23° C. for 12 hrs. The solution was then diluted with EtOAc and washed sequentially with saturated aqueous sodium bicarbonate and saturated aqueous sodium chloride (2×) solutions. The organic layer was dried over sodium sulfate. The residue was purified by flash chromatography to afford 4-isopropylamino-1-methoxy-[1,2,4]triazolo[4,3-a]quinoxaline-7-carboxylic acid-methoxy-methyl-amide. MS (M+H)+=345.7.

Provenance & Evidence