Cornforth reagent → HCID 10287620, compound

Participants

Reaction Steps

4-[3-(2,4-Dimethoxy-5-thiophen-2-yl-phenyl)-1-hydroxy-prop-2-ynyl]-benzoic acid methyl ester (2.0 g, 4.90 mmol) from Ex-1C was dissolved in dichloromethane (60 mL). Pyridinium dichromate (3.70 g, 9.8 mmol) was added and the resulting mixture was stirred at room temperature under nitrogen for 5 h. The reaction was then filtered through a pad of celite and concentrated under reduced pressure. Silica gel chromatography (dichloromethane/methanol, 30:1) gave 1.5 g (75%) of the desired 4-[3-(2,4-dimethoxy-5-thiophen-2-yl-phenyl)-propynoyl]-benzoic acid methyl ester as a yellow solid, m.p. 198–200° C. 1H-NMR (300 MHz, CDCl3) δ 8.38 (d, 2H, J=8.0 Hz), 8.17 (d, 2H, J=8.0 Hz), 0.88 (s, 1H), 7.41 (dd, 1H, J=3.7 and 1.6 Hz), 7.33 (dd, 1H, J=5.2 and 1.6 Hz), 7.09 (dd, 1H, J=5.2 and 3.7 Hz), 6.55 (s, 1H), 4.05 (s, 3H), 4.01 (s, 3H), 4.00 (s, 31H); EIMS m/z 406 (M+).

Provenance & Evidence