化工社化工社 化学情報印刷レポート · 研究参考用
HRID 1270275作成日：2026年10月27日
Ammonia → 4-Amino-7-[3,5-bis-o-(2,4dichlorophenylmethyl)-2-c-vinyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine
https://huagongshe.com/reaction/1270275
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | 4-Chloro-7-[3,5-bis-o-(2,4-dichlorophenylmethyl)-2-c-vinyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine | HCID 87285362 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-Amino-7-[3,5-bis-o-(2,4dichlorophenylmethyl)-2-c-vinyl-beta-d-ribofuranosyl]-7h-pyrrolo[2,3-d]pyrimidine | HCID 67142614 | — |
反応手順
The compound from Step B (80, mg) was dissolved in the minimum amount of 1,4-dioxane and placed in a stainless steel bomb. The bomb was cooled to −78° C. and liquid ammonia was added. The bomb was sealed and heated at 90° C. for 24 h. The ammonia was allowed to evaporate and the residue concentrated to a white solid which was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07202224B2 |
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| 出典データセット | uspto-grants-2007_04 |
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| ORD ID | ord-a9489cc6ae6843fd9d5a2c9cfa598639 |
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| 出典メモ | uspto-grants-2007_04 |
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