huagongshe.com
HRID1270282

反应详情

EQUATION

反应方程式

HRID 1270282 的结构方程式

REACTANTS

反应物

1
结构：Nc1ncnc2c1ccn2[C@@H]1O[C@H](COCc2ccc(Cl)cc2Cl)[C@@H](OCc2ccc(Cl)cc2Cl)[C@]1(O)CF
HCID21050081

未命名化合物

PRODUCTS

生成物

1
结构：Nc1ncnc2c1ccn2[C@@H]1O[C@H](CO)[C@@H](O)[C@]1(O)CF
HCID9966023

未命名化合物

收率 103.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
溶剂HCID23938

Palladium

Pd

结构：CO.ClCCl
溶剂HCID21226129

未命名化合物

PROCEDURE

实验过程

The compound from Step B (16 mg) was dissolved in 1:1 methanol/dichloromethane, 10% Pd—C was added, and the suspension stirred under an H2 atmosphere for 12 h. The catalyst was removed by filtration through a celite pad and washed with copious amounts of methanol. The combined filtrate was evaporated in vacuo and the residue was purified by flash chromatography (SiO2, 10% methanol in EtOAc containing 0.1% triethylamine) to give the title compound (8 mg) as a white powder.

WORKUP

后处理

  1. additionwas added
  2. customThe catalyst was removed by filtration through a celite pad
  3. washwashed with copious amounts of methanol
  4. customThe combined filtrate was evaporated in vacuo
  5. customthe residue was purified by flash chromatography (SiO2, 10% methanol in EtOAc containing 0.1% triethylamine)