反应详情

温度

90 °C

A solution of 4.0 g (10.80 mmol) of 2-(4-bromophenyl)-5,7-dimethyl-4-(1H-1,2,4-triazol-1-yl)imidazo[5,1-f][1,2,4]triazine from example 13A in DMF is treated with 2.97 g (16.21 mmol) of 3,4,5-trimethoxyaniline and 2.24 g (16.21 mmol) of potassium carbonate. The reaction mixture is stirred overnight at 90° C. After cooling, the solvent is removed on a rotary evaporator, the residue is treated twice more with toluene and the toluene is stripped off again. The crude product is extracted by stirring with a little methanol and filtered off with suction.

1. temperatureAfter cooling
2. customthe solvent is removed on a rotary evaporator
3. additionthe residue is treated twice more with toluene
4. extractionThe crude product is extracted
5. stirringby stirring with a little methanol
6. filtrationfiltered off with suction