反应详情

70 mg (0.17 mmol) of 5,7-dimethyl-2-(4-nitrophenyl)-4-(3,4,5-trimethoxyphenoxy)-imidazo[5,1-f][1,2,4]triazine from example 14A are dissolved in methanol under argon. The mixture is treated with 20 mg of palladium on carbon (10% strength). It is hydrogenated for 5 h at a hydrogen pressure of 3 bar. The catalyst is then filtered off from the reaction mixture and the filtrate is concentrated under reduced pressure. The residue is purified by chromatography. (Eluent:dichloromethane/methanol 80:1).

1. filtrationThe catalyst is then filtered off from the reaction mixture
2. concentrationthe filtrate is concentrated under reduced pressure
3. customThe residue is purified by chromatography