反应详情

温度

100 °C

28 mg (0.29 mmol) of sodium tert-butoxide are introduced into a second Schlenk tube under argon. Subsequently, 100 mg (0.21 mmol) of 2-(4-bromophenyl)-5,7-dimethyl-4-(3,4,5-trimethoxyphenoxy)imidazo[5,1-f][1,2,4]triazine from Exam-ple 16A, 22 mg (0.25 mmol) of morpholine and 2 ml of anhydrous toluene are added. Solution A is likewise added, and the whole is stirred overnight at 100° C. After cooling, the mixture is then filtered off with suction through a glass frit. The filtrate is concentrated to dryness under reduced pressure and purified by flash chromatography (cyclohexane/ethyl acetate 10:1-4:1-3:2-1:1).

1. temperatureAfter cooling
2. filtrationthe mixture is then filtered off with suction through a glass frit
3. concentrationThe filtrate is concentrated to dryness under reduced pressure
4. custompurified by flash chromatography (cyclohexane/ethyl acetate 10:1-4:1-3:2-1:1)