3-Pentanamine → HCID 22249036, compound

HRID 1270325Notes

Reaction equation

HRID 1270325 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[CH2:9]([CH:11]([NH2:14])[CH2:12][CH3:13])[CH3:10]>CCO>[CH3:10][CH2:9][CH:11]([NH:14][C:2]1[CH:7]=[N:6][CH:5]=[C:4]([Cl:8])[N:3]=1)[CH2:12][CH3:13]

Participants

4

Reactant 2

HCID 120193-PentanamineHCID 785042,6-Dichloropyrazine

Product 1

HCID 22249036HCID 22249036, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2,6-dichloropyrazine (2.2 g) and 1-ethylpropylamine (5 mL) in EtOH (10 mL) is heated at 140° C. in a Teflon-sealed tube. Resulting solution is concentrated in vacuo, diluted by water, and extracted twice with hexane-ethyl ether. Combined extracts are dried (sodium sulfate), filtered, concentrated in vacuo, and the residue is filtered through a short pad of silica gel. The filtrate is concentrated to give 2-(3-pentylamino)-6-chloropyrazine as brownish oil that solidifies on standing (3.0 g).

Workup

  1. customsealed tube
  2. concentrationResulting solution is concentrated in vacuo
  3. additiondiluted by water
  4. extractionextracted twice with hexane-ethyl ether
  5. dry with materialCombined extracts are dried (sodium sulfate)
  6. filtrationfiltered
  7. concentrationconcentrated in vacuo
  8. filtrationthe residue is filtered through a short pad of silica gel
  9. concentrationThe filtrate is concentrated

Sources & evidence

ORD record
ord-7a4c9edf41c544bcb2f0efeec7c99b2a
Source dataset
uspto-grants-2007_04
Patent number
US07202250B2

Reaction notes

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