N-methyl-2-pyrrolidone → HCID 69433518, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(3-pentylamino)-6-chloropyrazine (3.3 g, 16.5 mmol) (obtained in example 75) in 1-methyl-2-pyrrolidinone (15 mL) at room temperature is added a solution of sodium methoxide in methanol (5.0M, 10 ml). The resulting solution was heated to 50° C. for 20 h then evaporated and poured into water and extracted twice with ethyl acetate/hexane (1:1). Combined extracts were dried (sodium sulfate), filtered, concentrated, and chromatographed to give N-(1-ethyl)propyl-6-methoxypyrazine-2-amine as a light yellow solid(98%).

Provenance & Evidence