反应详情

A solution of {6-methoxy-5-[2-methoxy4-(trifluoromethoxy)phenyl]pyrazin-2-yl }[(4-methoxyphenyl)methyl]amine (870 mg, 2.0 mmol) in chloroform (10 mL) is cooled to 0° C. and N-bromosuccinimide (356 mg, 2.0 mmol) is added in portions. After the addition, the mixture is further stirred for 1 h while being allowed to warm to room temperature. The mixture is washed with saturated aqueous sodium bicarbonate, aqueous sodium chloride, dried (magnesium sulfate), filtered, and evaporated to give {3-bromo-6-methoxy-5-[2-methoxy-4-(trifluoromethoxy)phenyl]pyrazin-2-yl }[(4-methoxyphenyl)methyl]amine (920 mg), a yellow solid.

1. additionAfter the addition
2. washThe mixture is washed with saturated aqueous sodium bicarbonate, aqueous sodium chloride
3. dry with materialdried (magnesium sulfate)
4. filtrationfiltered
5. customevaporated