Aniline → Ammonium Hydroxide

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2-chloro-3-nitropyridine (500 mg, 3.15 mmol) and aniline (587 mg, 6.30 mmol) in EtOH (1.5 mL) was heated in a microwave reactor for 10 min at 150° C., then concentrated in vacuo. The crude product was purified by silica gel chromatography, eluting with a gradient of CH2Cl2:MeOH:NH4OH—100:0:0 to 95:5:0.25, to provide the title compound as a solid. MS: m/z=216 (M+1).

Provenance & Evidence