Potassium Acetate → HCID 18449359, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-hydroxybenzimidazole (1.20 g, 8.95 mmol), 2,4-dibromothiazole (6.5 g, 26.8 mmol), copper powder (1.42 g, 22.37 mmol), CuCl (177 mg, 1.79 mmol), and KOAc (2.2 g, 22.37 mmol) in pyridine (10 mL) were heated at 60° C. for 2 h. The cooled mixture was partitioned between EtOAc (40 mL) and 10% aqueous citric acid (20 mL) and the organic layer was dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography, eluting with a gradient of hexane:EtOAc—100:0 to 50:50, to give the title compound. MS: m/z=297 (M+1).

Provenance & Evidence