Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetate → (6-Bromo-2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetic acid

HRID 1270407Notes

Reaction equation

HRID 1270407 reaction equation
O=C1[N:6](CC(OC(C)(C)C)=O)[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18]C=2N1.[Br:19][C:20]1[CH:21]=[CH:22][C:23]2[NH:27][C:26](=[O:28])[N:25]([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[C:24]=2[CH:37]=1>>[Br:19][C:20]1[CH:21]=[CH:22][C:23]2[N:27]([C:18]3[CH:17]=[CH:16][CH:15]=[CH:5][N:6]=3)[C:26](=[O:28])[N:25]([CH2:29][C:30]([OH:32])=[O:31])[C:24]=2[CH:37]=1

Participants

3

Reactant 2

HCID 20814117Tert-butyl (2-oxo-2,3-dihydrobenzimidazol-1-yl)acetateHCID 86607790tert-Butyl (6-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetate

Product 1

HCID 18449396(6-Bromo-2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetic acid

Procedure

Essentially following the procedures described for Intermediate 4, but using tert-butyl (6-bromo-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)acetate in place of tert-butyl (2-oxo-3-pyridin-2-yl-2,3-dihydro-1H-benzimidazol-1-yl)acetate, the title compound was prepared. MS: m/z=348 (M+1).

Sources & evidence

ORD record
ord-65c5fa2dc56d40429f16448c87fb06fe
Source dataset
uspto-grants-2007_04
Patent number
US07202251B2

Reaction notes

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