Carbon Tetrachloride → HCID 86598335, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (3,5-bis(trifluoromethyl)phenyl)-[(3R,6R,8aR)-6-hydroxymethyl-3-(1H-indol-3-ylmethyl)-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-methanone (1.30 g), triphenylphosphine (1.2 g), carbontetrachloride (4 mL), and acetonitrile (40 mL) was heated at 70° C. for 6 hours. After cooling to room temperature the solvent was removed in vacuo. The residue was purified by ion-exchange chromatography on a strong cation exchange (SCX) column, to afford 3,5-bis(trifluoromethyl)phenyl-[(3R,6R,8aR)-6-chloromethyl-3-(1H-indol-3-ylmethyl)-hexahydropyrrolo[1,2-a]pyrazin-2-yl]-methanone (1.06 g) (Intermediate 5).

Provenance & Evidence