HCID 18449632, compound → HCID 136166451, compound

Participants

Reaction Steps

The amide (73 mg, 0.217 mmol) in EtOH (1 mL) and 2N NaOH (1 mL) was heated at 80° C. for 1 h. The reaction mixture was concentrated, extracted with CH2Cl2 (3×) then dried over anhydrous sodium sulfate. Purification by flash chromatography (1:1, hexane-EtOAc) gave 2-(1-phenyl-cyclohexylmethyl)-3H-quinazolin-4-one (66 mg, 96%) as a white solid. Mass Spec [M+H]+=319.2.

Provenance & Evidence