Hydrochloric Acid → HCID 12093204, compound

Participants

Reaction Conditions

Reaction Steps

Under nitrogen, 2 g of 7-chloro-2-methyl-1-[3-(methylsulfonylamino)propyl]indole are dissolved in 16 ml of TCE at AT and 0.645 ml of oxalyl chloride in 7 ml of TCE is added. The mixture is heated at 120° C. for 16 hours and then cooled to AT. The reaction medium is diluted by adding 20 ml of water and is then poured onto 50 ml of a 10% HCl solution. The mixture is separated by settling out and the aqueous phase is then washed with DCM. The organic phases are combined and then washed with a saturated NaCl solution. Drying over Na2SO4 followed by concentration to dryness are performed and the product is purified by chromatography on silica, elution being carried out with CH2Cl2-MeOH (95/5; v/v). 1.33 g of the expected compound are obtained.

Provenance & Evidence