HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → 1-[3-t-Butyl-1-(4-formylphenyl)-1h-pyrazol-5-yl]-3-(naphthalen-1-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | 1-[2-(4-Hydroxymethyl-phenyl)-5-isopropyl-2h-pyrazol-3-yl]-3-naphthalen-1-yl-urea | HCID 18449827 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Product | 1-[3-t-Butyl-1-(4-formylphenyl)-1h-pyrazol-5-yl]-3-(naphthalen-1-yl)urea | HCID 18449874 | — |
Reaction Steps
To a solution of Example 204 (200 mg) in CH2Cl2 (50 mL) was added MnO2 (450 mg) at RT. The suspension was stirred for 2 h then filtered through celite. The filtrate was concentrated under reduced pressure to afford 150 mg of 1-[5-t-butyl-2-(4-formyl-phenyl)-2H-pyrazol-3-yl]-3-naphthalen-1-yl-urea, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07202257B2 |
| Source dataset | uspto-grants-2007_04 |
| ORD ID | ord-f286df3dc7a844c88073ddc8604de77f |
| Source note | uspto-grants-2007_04 |