4-(3-Bromo-4-methoxyphenoxy)-3,5-dimethylnitrobenzene → 4-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenylamine

HRID 1270605노트

반응식

HRID 1270605 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[O:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([N+:13]([O-])=O)=[CH:8][C:7]=1[CH3:16]>[Pd].C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[O:5][C:6]1[C:11]([CH3:12])=[CH:10][C:9]([NH2:13])=[CH:8][C:7]=1[CH3:16]

참가 물질

4

반응물 1

HCID 223397284-(3-Bromo-4-methoxyphenoxy)-3,5-dimethylnitrobenzene

생성물 1

HCID 223395024-(3-Bromo-4-methoxy-phenoxy)-3,5-dimethyl-phenylamine수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A mixture of the title product of Step A (5.0 g) and 10% palladium on carbon (0.6 g) in ethyl acetate (100 ml) was hydrogenated at 50 psi for 3 h. The reaction was filtered through Celite and concentrated to afford the title compound of Step B as a yellow solid (4.3 g). MS (APCI+) Calc: 321; Found 322 (M+1).

후처리

  1. filtrationThe reaction was filtered through Celite
  2. concentrationconcentrated

출처 및 근거

ORD 기록
ord-b61df12010b442ab977621dfdc206ed3
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07202275B2

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