Hydrochloric Acid → HCID 11515081, compound

Participants

Reaction Conditions

Reaction Steps

Under nitrogen atmosphere and at 5° C., 129 ml of 1.6M n-butyllithium in hexane was added to a mixture of 16.8 g of 1,1,1,3,3,3-hexafluoro-2-propanol and 120 g of tetrahydrofuran, which was stirred for one hour at 5° C. Next, 14.2 g of 2-oxopropyl methacrylate was added at 5° C. The mixture was stirred for 10 hours, after which dilute hydrochloric acid was added to stop the reaction and neutralize the reaction mixture. Through conventional aqueous work-up and purification by silica gel column chromatography, 25.3 g of the target compound was obtained (yield 82%).

Provenance & Evidence