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HRID 1270620作成日：2026年10月26日

2-(4-Methoxyphenyl)-1,1-dimethylethylamine → N-[2-Hydroxy-3-(2-chlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine Hydrochloride

https://huagongshe.com/reaction/1270620

反応式

関与物質

役割名称HCID仕込み量
反応物2-(4-Methoxyphenyl)-1,1-dimethylethylamineHCID 91892—
反応物2-(2-Chlorophenoxymethyl)oxiraneHCID 137500—
生成物N-[2-Hydroxy-3-(2-chlorophenoxy)propyl]-1,1-dimethyl-2-(4-methoxyphenyl)ethylamine HydrochlorideHCID 22640862139.4%

反応手順

Using the method of Example 25, supra, 2-chlorophenyl glycidyl ether (1.0 mmol) and 1,1-dimethyl-2-(4-methoxyphenyl)ethylamine (1.25 mmol) yielded 279 mg of the title compound as a white solid: GC/EI-MS, m/z (rel. int.) 348 (M−15, 5), 245 (21), 244 (100), 242 (100), 163 (29), 121 (82), 114 (24), 77 (21), 71 (44), 70 (56), 58 (24).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07202261B2
出典データセットuspto-grants-2007_04
ORD IDord-e06f29d643e2415b8162d5f79a64a5fc
出典メモuspto-grants-2007_04