Iodobenzene → 5-(4-methylphenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole

HRID 1270700Notes

Reaction equation

HRID 1270700 reaction equation
[F:1][C:2]([F:16])([F:15])[C:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=2)[NH:5][N:4]=1.I[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:18]1([N:5]2[C:6]([C:8]3[CH:9]=[CH:10][C:11]([CH3:14])=[CH:12][CH:13]=3)=[CH:7][C:3]([C:2]([F:1])([F:15])[F:16])=[N:4]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 11575IodobenzeneHCID 178423762HCID 178423762, compound

Product 1

HCID 103350645-(4-methylphenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole

Procedure

This compound was isolated by silica gel chromatography following arylation of 3-trifluoromethyl-5-(p-tolyl)-1H pyrazole using iodobenzene as described in Example 1.1.

Workup

  1. customThis compound was isolated by silica gel chromatography

Sources & evidence

ORD record
ord-c2b94ff6d22b49e3b3abe423ec635dec
Source dataset
uspto-grants-2007_04
Patent number
US07202367B2

Reaction notes

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