Iodobenzene → 1-Phenylpyrrolidin-2-one

HRID 1270701Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].I[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([N:1]2[CH2:5][CH2:4][CH2:3][C:2]2=[O:6])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 11575Iodobenzene

HCID 120252-Pyrrolidone2×

Product 1

HCID 783751-Phenylpyrrolidin-2-one

Procedure

Example 2.1 was repeated, replacing the oxazolidin-2-one with 152 μl of pyrrolidin-2-one (2 mmoles) and operating with 336 μl of iodobenzene (3 mmoles), the latter being added at the same time as the pyrrolidin-2-one.

Sources & evidence

ORD record: ord-6751a0b00eb843f994b041fe440b14d0
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07202367B2

Reaction notes

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