2-Iodotoluene → 1,3-Dimethyl-5-(2-methylphenoxy)benzene

HRID 1270703Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([CH3:8])[CH:7]=1.IC1C=CC=CC=1.I[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[CH3:24]>>[CH3:24][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=1[O:9][C:4]1[CH:5]=[C:6]([CH3:8])[CH:7]=[C:2]([CH3:1])[CH:3]=1

Participants

Reactant 3

HCID 51282-Iodotoluene

HCID 79483,5-Dimethylphenol

HCID 11575Iodobenzene

Product 1

HCID 153249461,3-Dimethyl-5-(2-methylphenoxy)benzene

Procedure

Example 3.1 was repeated, replacing the phenol with 244 mg of 3,5-dimethylphenol (2 mmoles) and the iodobenzene with 383 μl of 2-iodotoluene (3 mmoles), and taking the reaction time to 118 hours.

Workup

customto 118 hours

Sources & evidence

ORD record: ord-38bcc34d526341779696ce8ac968cc71
Source dataset: uspto-grants-2007_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07202367B2

Reaction notes

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