Lithium hydroxide, monohydrate → HCID 18451488, compound

Participants

Reaction Steps

A mixture of 1.43 g (5.34 mmol) of N-(1-fluoro-3-chloro-2-naphthyl)carbamic acid ethyl ester, and 4.48 g (106.8 mmol) LiOH.H2O in 30 mL of EtOH and 70 mL of H2O is heated to reflux for 16 hours under an atmosphere of nitrogen. After cooling to room temperature, the mixture is concentrated in vacuo to give a residue that is extracted 3 times with 30 mL CH2Cl2. The combined organic layers are washed with 30 mL of saturated aqueous NaHCO3, 30 mL of saturated brine, dried over MgSO4 and the solvents evaporated to give 1-fluoro-3-chloro-2-aminonaphthalene as a brown solid.

Provenance & Evidence