反应详情

温度

120 °C

A mixture of 2-iodo-7-nitronaphthalene (1 g, 3.34 mmol), trifluoromethyliodide (0.328 mL, 4.01 mmol) and copper powder (2.55 g, 40.1 mmol) in pyridine (20 mL) in a sealed tube is heated with stirring at 120° C. for 20 hours. After cooling, the reaction mixture is filtered and extracted with EtOAc. The organic extracts are washed with water, 0.1 M citric acid solution and dried (Na2SO4). Concentration and purification of the residual oil by flash chromatography on silica gel (2:1 hexanes/EtOAc) gives 2-nitro-7-trifluoromethylnaphthalene as a yellow solid.

1. temperatureis heated
2. temperatureAfter cooling
3. filtrationthe reaction mixture is filtered
4. extractionextracted with EtOAc
5. washThe organic extracts are washed with water, 0.1 M citric acid solution
6. dry with materialdried (Na2SO4)
7. concentrationConcentration and purification of the residual oil by flash chromatography on silica gel (2:1 hexanes/EtOAc)