反应详情

To a solution of 6-amino-2-naphthoic acid (1 g, 5.34 mmol) in ethanol (20 mL), is added dropwise thionyl chloride (0.622 mL, 10.7 mmol). The resulting reaction solution is heated to reflux temperature under a N2 atmosphere for 3 hours. Concentration and trituration with methanol gives 6-amino-2-naphthoic acid ethyl ester as a brown oil.

1. customThe resulting reaction solution
2. temperatureis heated
3. temperatureto reflux temperature under a N2 atmosphere for 3 hours
4. concentrationConcentration and trituration with methanol