反应详情

温度

110 °C

A mixture of 6-amino-2-naphthoic acid ethyl ester (500 mg, 2.32 mmol) and nitrosonium tetrafluoroborate (298 mg, 2.56 mmol) in 1,2-dichlorobenzene (10 mL) is stirred at room temperature for 12 hours and at 110° C. for 1 hour. After cooling to room temperature, the reaction mixture is concentrated by rotary evaporator under high vacuum. The residual oil is purified by flash chromatography on silica gel (dichloromethane) to give 6-fluoro-2-naphthoic acid ethyl ester as a yellow oil.

1. temperatureAfter cooling to room temperature
2. concentrationthe reaction mixture is concentrated by rotary evaporator under high vacuum
3. customThe residual oil is purified by flash chromatography on silica gel (dichloromethane)