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Water → 6-Fluoro-2-naphthoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Ethyl 6-fluoro-2-naphthoate | HCID 68806046 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 6-Fluoro-2-naphthoic acid | HCID 2782788 | — |
反応手順
To a solution of 6-fluoro-2-naphthoic acid ethyl ester (600 mg, 2.75 mmol) in ethanol (10 mL) at room temperature, is added 1 N NaOH (2.75 mL, 2.75 mmol). After stirring at room temperature for 4 hours, water (10 mL) is added. Acidification (2 N HCl) and filtration gives 6-fluoro-2-naphthoic acid as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07202364B2 |
| 出典データセット | uspto-grants-2007_04 |
| ORD ID | ord-beb3c2a74c504d8183c0a7a6eab40b50 |
| 出典メモ | uspto-grants-2007_04 |