Ammonia → HCID 18451519, compound

Participants

Reaction Steps

A solution of 4,7-dichloro-2-trifluoromethylquinoline (2 g, 7.52 mmol) in dioxane (10 mL) and NH3 (2 mL) are mixed at −78° C. in a sealed tube. After sealing and warming up to room temperature, the reaction is heated at 60–70° C. for 19 hours and at 120° C. for 3 hours. The sealed tube is cooled to −78° C. before it is opened and the contents are concentrated by rotary evaporator. 4-Amino-7-chloro-2-trifluoromethylquinoline is obtained as a solid by trituration of the residue with ether.

Provenance & Evidence