Potassium Carbonate → HCID 86593361, compound

Participants

Reaction Steps

A mixture of N,N-dimethyl-2-bromo-5-cyclopropylphenylacetamide (1.0 g), 2-fluoro-4-(4-fluorophenyl)aniline (1.5 g), K2CO3 (490 mg), KI (590 mg), Cu (113 mg), CuI (337 mg) in xylenes (10 mL) is heated to reflux for 48 hours. After cooling, the reaction is filtered through silica gel and the filtrate concentrated to a brown oil. The oil is purified by flash chromatography using 10%, then 20%, then 30%, then 40% EtOAc in hexane to give the title product as a foam.

Provenance & Evidence