Valeryl chloride → 1-Heptyn-3-one, 1-(trimethylsilyl)-

HRID 127081Notes

Reaction equation

HRID 127081 reaction equation
[C:1](Cl)(=[O:6])[CH2:2][CH2:3][CH2:4][CH3:5].[CH3:8][Si:9]([C:12]#[C:13][Si](C)(C)C)([CH3:11])[CH3:10].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:8][Si:9]([C:12]#[C:13][C:1]([CH2:2][CH2:3][CH2:4][CH3:5])=[O:6])([CH3:11])[CH3:10]

Participants

5

Reactant 3

HCID 61186Valeryl chlorideHCID 84564Bis(trimethylsilyl)acetyleneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 110195111-Heptyn-3-one, 1-(trimethylsilyl)-Yield 76%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of 14.4 g of valeryl chloride and 20.4 g of bis-trimethylsilylacetylene in 300 ml of dry methylene chloride, cooled in an ice bath, is added powdered anhydrous aluminum chloride, portionwise, over a period of 20 minutes. The mixture is stirred for 5 minutes, then the cooling bath is removed and the mixture is stirred at room temperature for 4 hours. The mixture is poured into 500 ml of ice-water. The organic layer is separated, washed with water and brine, dried over anhydrous sodium sulfate and filtered through diatomaceous earth. The mother liquor is evaporated to dryness giving a brownish residue. This residue is Kugelrohr-distilled to give 16.56 g of colorless liquid at 45° C./0.3 mm which is essentially identical with the authentic product.

Workup

  1. additionis added
  2. customthe cooling bath is removed
  3. stirringthe mixture is stirred at room temperature for 4 hours
  4. additionThe mixture is poured into 500 ml of ice-water
  5. customThe organic layer is separated
  6. washwashed with water and brine
  7. dry with materialdried over anhydrous sodium sulfate
  8. filtrationfiltered through diatomaceous earth
  9. customThe mother liquor is evaporated to dryness
  10. customgiving a brownish residue
  11. distillationThis residue is Kugelrohr-distilled

Sources & evidence

ORD record
ord-74b42331a11245078ff99d4880a6e33e
Source dataset
uspto-grants-1981_03
Patent number
US04254285

Reaction notes

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