Piperidine → HCID 178450148, Verbindung

HRID 1270830Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1270830
N1CCCCC1.C1C2C(COC(=O)[NH:23][CH:24]([CH2:48][C:49]3[CH:54]=[CH:53][C:52]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[CH:51][CH:50]=3)[C:25](=[O:47])[N:26]3[CH:35]([C:36]4[NH:37][CH:38]=[C:39]([C:41]5[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=5)[N:40]=4)[CH2:34][C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[CH2:27]3)C3C(=CC=CC=3)C=2C=CC=1>CO>[NH2:23][CH:24]([CH2:48][C:49]1[CH:54]=[CH:53][C:52]([O:55][C:56]([CH3:59])([CH3:58])[CH3:57])=[CH:51][CH:50]=1)[C:25]([N:26]1[CH:35]([C:36]2[NH:37][CH:38]=[C:39]([C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[N:40]=2)[CH2:34][C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:27]1)=[O:47]

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 178450149HCID 178450149, Verbindung

Produkt 1

HCID 178450148HCID 178450148, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Piperidine in methanol (20%; 2 mL) was added to {1-(4-tert-butoxy-benzyl)-2-oxo-2-[3-(4-phenyl-1H-imidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester (0.20 g, 0.28 mmol) at room temperature. After 30 minutes the reaction was concentrated under reduced pressure, and the residual 200 mg of desired product 2-amino-3-(4-tert-butoxy-phenyl)-1-[3-(4-phenyl-1H-imidazol-2-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-propan-1-one was used as is without further purification (LC/MS; Measured, MW (MH+):495).

Aufarbeitung

  1. concentrationAfter 30 minutes the reaction was concentrated under reduced pressure
  2. customas is without further purification (LC/MS; Measured, MW (MH+):495)

Quellen und Nachweise

ORD-Eintrag
ord-c5bf65ca101f4c9e9b9313568e52711f
Quelldatensatz
uspto-grants-2007_04
Patentnummer
US07202381B2

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