1-Methyl-1H-indole-2-carbonyl chloride → N-[4-(4-amino-7-{[3-(4-hydroxypiperidin-1-yl)propanoyl]amino}thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Methyl-1H-indole-2-carbonyl chloride	HCID 12303314	—
Reactant	N-[4-Amino-3-(4-amino-3-methoxyphenyl)-thieno[3,2-c]pyridin-7-yl]-3-(4-hydroxy-piperidin-1-yl)propionamide	HCID 18451406	—
Product	N-[4-(4-amino-7-{[3-(4-hydroxypiperidin-1-yl)propanoyl]amino}thieno[3,2-c]pyridin-3-yl)-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide	HCID 18451117	—

Reaction Steps

The title compound was prepared using 1-methyl-1H-indole-2-carbonyl chloride, N-[4-Amino-3-(4-amino-3-methoxyphenyl)-thieno[3,2-c]pyridin-7-yl]-3-(4-hydroxy-piperidin-1-yl)propionamide, and the procedure described in General Procedure F. m/z (M+H)+ 599.4.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07202363B2
Source dataset	uspto-grants-2007_04
ORD ID	ord-f1783cbbd1784296a02f5580979c3c3e
Source note	uspto-grants-2007_04