HCID 11272398, compound → HCID 178512284, compound

Participants

Reaction Steps

Prepared as in Example 8 from [(S)-1-benzyl-2-(2-pyrrolidin-1-yl-ethylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester (Example 27, step A) and 1-[4-(4-chloro-phenoxy)-phenyl]-3-cyano-thiourea (Example 32, step A). MS (electrospray): mass calculated for C30H33ClN6O2, 544.24; m/z found, 545.2 [M+H]+. 1H NMR (400 MHz, CDCl3): 7.27–7.08 (m, 9H), 6.91 (t, J=9.4 Hz, 4H), 6.25 (br s, 1H), 4.35–4.26 (m, 1H), 3.35–3.28 (m, 1H), 3.25–3.17 (m, 1H), 2.99 (dd, J=13.5, 6.4 Hz, 1H), 2.7–2.68 (m, 1H), 2.52 (t, J=5.9 Hz, 2H), 2.49–2.41 (m, 4H), 2.41–2.35 (m, 1H), 2.26–2.18 (m, 1H), 1.74–1.69 (m, 6H).

Provenance & Evidence