N-Methylethylenediamine → HCID 11271631, compound

Participants

Reaction Steps

Prepared as in Example 18, step B, from (E)-(S)-4-(3-biphenyl-4-yl-ureido)-5-phenyl-pent-2-enoic acid (Example 19, step A), substituting 2-pyrrolidin-1-yl-ethylamine for N′-methyl-ethane-1,2-diamine. MS (electrospray): mass calculated for C30H3N4O2, 482.27; m/z found, 483.3 [M+H]+, 505.2 [M+Na]+, 987.5 [2M+H]+. 1H NMR (400 MHz, CDCl3): 7.99 (s, 1H), 7.53 (d, J=7.4 Hz, 2H), 7.49–7.37 (m, 7H), 7.32–7.20 (m, 5H), 6.80 (dd, J=15.3, 5.1 Hz, 1H), 5.97–5.93 (m, 2H), 4.89–4.83 (m, 1H), 4.51–4.45 (m, 1H), 3.63–3.55 (m, 1H), 3.28–3.21 (m, 1H), 2.95 (dd, J=13.7, 7.3 Hz, 1H), 2.87 (dd, J=13.7, 7.3 Hz, 1H), 2.72–2.65 (m, 2H), 2.53–2.45 (m, 4H), 1.78–1.69 (m, 4H).

Provenance & Evidence