反应详情

To a solution of potassium hydroxide (2.9 g.) in water (80 ml.) was added ethyl 2-methanesulfonamidothiazol-4-ylacetate (9.1 g.) under ice-cooling and stirring, and the mixture was stirred for 1 hour at room temperature. After the reaction, to the reaction mixture was added a mixture of water and ethyl acetate, and then the aqueous layer was separated. The remaining ethyl acetate layer was extracted twice with 10% hydroxide aqueous solution. The extracts were combined with the above obtained aqueous layer, and the mixture was acidified with hydrochloric acid under ice-cooling. The precipitated crystals were collected by filtration, washed with water and dried to give 2-methanesulfonamidothiazol-4-ylacetic acid (5.94 g.), mp 158°-160° C. (dec.).

1. temperaturecooling
2. stirringthe mixture was stirred for 1 hour at room temperature
3. customAfter the reaction
4. additionto the reaction mixture was added
5. customthe aqueous layer was separated
6. extractionThe remaining ethyl acetate layer was extracted twice with 10% hydroxide aqueous solution
7. temperaturecooling
8. filtrationThe precipitated crystals were collected by filtration
9. washwashed with water
10. customdried