反应详情

A mixture of 1.0 g of 4-ethynylaniline and 2.4 mL of acetic anhydride in 5.0 mL of dichloromethane was stirred at room temperature for 18 hours. The solution was evaporated in vacuo at 40° C. The resulting semi solid mixture was suspended in hexanes and filtered. The hexanes filtrate was washed twice with water and dried over sodium sulfate. After filtering it was combined with the hexanes insoluble residue, dissolved in dichloromethane and purified by column chromatography in the same solvent to yield 0.96 g of 1-acetamido-4-ethynylbenzene.

1. customThe solution was evaporated in vacuo at 40° C
2. filtrationfiltered
3. washThe hexanes filtrate was washed twice with water
4. dry with materialdried over sodium sulfate
5. filtrationAfter filtering it
6. dissolutiondissolved in dichloromethane
7. custompurified by column chromatography in the same solvent