HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1271056Generated: October 26, 2026
Sodium Iodide → 5-Iodo-3-methylpyridin-2-amine
https://huagongshe.com/reaction/1271056
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | 2,3-Butanediamione, 2,3-dimethyl- | HCID 123390 | — |
| Reactant | 2-Amino-5-bromo-3-methylpyridine | HCID 137934 | — |
| Catalyst | Copper iodide | HCID 83717 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-Iodo-3-methylpyridin-2-amine | HCID 959586 | 93% |
Reaction Steps
To dioxane (10 mL) was added 5-bromo-3-methylpyridin-2-amine (2 g, 10.6 mmol), sodium iodide (3.2 g, 21.4 mmoL), copper iodide (0.190 g, 1.06 mmol) and the solution degassed followed by addition of tetramethylethane-1,2-diamine (0.803 mL, 1.06 mmol) this mixture heated at 110° C. overnight. After cooling water was added and extracted the crude product with ethyl acetate. The residue was purified by column chromatography to give 5-iodo-3-methylpyridin-2-amine as a beige solid (2.3 g, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07205296B2 |
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| Source dataset | uspto-grants-2007_04 |
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| ORD ID | ord-43d6e3a73cb3456fbaf97377735b77fa |
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| Source note | uspto-grants-2007_04 |
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