Methylamine → HCID 18452511, compound

Participants

Reaction Steps

Analogous to Ex. 3, methyl amine displacement was performed using 6-chloro-7-fluoro-3-(4-nitrophenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one (0.21 g, 0.16 mmol) and methyl amine (0.3 ml, 2M solution in tetrahydrofuran) to give 0.134 mg (81%) of 6-chloro-7-(methylamino)-3-(4-nitrophenyl)-2,3-dihydrobenzo[e][1,3]oxazin-4-one. RP-HPLC: 2.38 min; ES-MS (M+H)+=334; 1H-NMR (DMSO-d6) δ (ppm): 3.1 (s, 3), 5.73 (s, 2), 6.2 (d, 1), 7.38 (d, 1), 7.61 (d, 2), 8.2 (d, 2).

Provenance & Evidence