反应详情

(1R,5S/1S,5R) 5-iodo-3-(phenylcarbonyl)-1-(3-{1-[3-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione (Prep82, 250 mg, 0.410 mmol) was dissolved in 3% ammonia in MeOH, (4 mL, 5.55 mmol). The mixture was stirred at room temperature for 3 hours, the solvent was then evaporated under vacuum and the crude purified by SPE Si (20 g) with Toluene/acetone 80/20 to give a solid that was then loaded through a SCX (5 g) cartridge in order to recover the title compound (168 mg, 0.332 mmol, 81% yield) as a white solid.

1. customthe solvent was then evaporated under vacuum
2. customthe crude purified by SPE Si (20 g) with Toluene/acetone 80/20
3. customto give a solid