Hexane → HCID 58844211, compound

Participants

Reaction Conditions

Reaction Steps

Allyl (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-[3-(hydroxymethyl)phenyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate prepared in the above step, sodium 2-ethylhexanoate (242 mg) and triphenylphosphine (32 mg) were dissolved in THF (10 ml), and the solution was cooled to 0° C. Thereto tetrakis(triphenylphosphine) palladium(0) (70 mg) was added. Thirty minutes later, thereto hexane (3 ml) was added and then the solution was stirred for additional 30 minutes. The resulting crystals were filtered under nitrogen atmosphere, and dried under reduced pressure to give sodium (5R,6S)-6-[(1R)-1-hydroxyethyl]-3-[3-(hydroxymethyl)phenyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate (217 mg).

Provenance & Evidence