反应详情

To a solution of ethyl 2-aminothiazol-4-ylacetate (27.4 g.) in dimethylsulfoxide (135 ml.) was dropwise added methylisocyanate (13.05 g.) with stirring at room temperature, and the mixture was stirred for 3 hours at 40° C. After the reaction, the reaction mixture was poured into water (500 ml.), and then extracted with ethyl acetate. The extract was washed with water and a saturated aqueous solution of sodium chloride in turn and then dried over magnesium sulfate. After distillation of the solvent from the extract, the residue was pulverized in diethyl ether, collected by filtration and then dried to give colorless crystals of ethyl 2-(3-methylureido)thiazol-4-ylacetate (25.7 g.), mp 158° to 159° C.

1. stirringthe mixture was stirred for 3 hours at 40° C
2. customAfter the reaction
3. extractionextracted with ethyl acetate
4. washThe extract was washed with water
5. dry with materiala saturated aqueous solution of sodium chloride in turn and then dried over magnesium sulfate
6. distillationAfter distillation of the solvent from the extract
7. filtrationcollected by filtration
8. customdried