7-Bromo-5-methoxyindoline hydrochloride → HCID 10202741, compound

Participants

Reaction Steps

Prepared in a similar fashion as described for Example 413 using 3,5-dichloro-1-(1-ethylpropyl)-2(1H)-pyrazinone and 7-bromo-5-methoxyindoline hydrochloride as the starting materials. mp 130–132° C.; 1H NMR (300 MHz, CDCl3): δ 6.92 (d, J=2.6 Hz, 1 H), 6.78 (d, J=2.2 Hz, 1 H), 6.73 (s, 1 H), 4.81 (brs, 1 H), 4.35 (t, J=7.7 Hz, 2 H), 3.78 (s, 3 H), 3.11 (t, J=7.7 Hz, 2 H), 1.87–1.73 (m, 2 H), 1.70–1.60 (m, 2 H), 0.89 (s, 6 H); HRMS (ESI) calcd for C18H22N3O2BrCl (M+H)+: 426.0584; found m/z 426.0606.

Provenance & Evidence