反应详情

To a solution of ethyl 2-(3-methylureido)thiazol-4-ylacetate (12.8 g.) in a mixture of methanol (240 ml.) and water (240 ml.) was dropwise added 1 N potassium hydroxide aqueous solution (52.7 ml.) with stirring at room temperature, and the solution was stirred for overnight at the same temperature, and then methanol was distilled off therefrom under reduced pressure. The remaining aqueous layer was washed with ethyl acetate, and then 1 N hydrochloric acid (52.7 ml.) was added thereto under ice-cooling. The precipitated crystals were collected by filtration, washed with water and then dried to give colorless crystals of 2-(3-methylureido)thiazol-4-ylacetic acid (9.7 g.), mp 190° C. (dec.).

1. stirringthe solution was stirred for overnight at the same temperature
2. distillationmethanol was distilled off
3. washThe remaining aqueous layer was washed with ethyl acetate
4. addition1 N hydrochloric acid (52.7 ml.) was added
5. temperatureunder ice-cooling
6. filtrationThe precipitated crystals were collected by filtration
7. washwashed with water
8. customdried