反应详情

Prepared in a similar fashion as described for Example 413 using 1-sec-butyl-3,5-dichloro-2(1H)-pyrazinone and 5-methoxy-7-methylindoline hydrochloride as the starting materials. mp 176–178° C.; 1H NMR (300 MHz, CDCl3): δ 6.70 (s, 1 H), 6.66 (d, J=2.2 Hz, 1 H), 6.57 (d, J=2.2 Hz, 1 H), 4.98–4.91 (m, 1 H), 4.38 (t, J=7.7 Hz, 2 H), 3.77 (s, 3 H), 3.02 (t, J=7.7 Hz, 2 H), 2.04 (s, 3 H), 1.74–1.64 (m, 2 H), 1.33 (d, J=6.9 Hz, 3 H), 0.90 (t, J=7.5 Hz, 3 H); HRMS (ESI) calcd for C18H23N3O2Cl (M+H)+: 348.1479; found m/z 348.1490.

1. customPrepared in a similar fashion