HCID 18629224, compound → HCID 10299313, compound

Participants

Reaction Steps

Prepared in a similar fashion as described for Example 413 using 3,5-dichloro-1-[(1R)-2-methoxy-1-methylethyl]-2(1H)-pyrazinone and 5,7-dibromoindoline as the starting materials. mp 119–120° C.; 1H NMR (300 MHz, CDCl3): δ 7.47 (d, J=1.8 Hz, 1 H), 7.27 (d, J=1.8 Hz, 1 H), 7.06 (s, 1 H), 5.14–5.09 (m, 1 H), 4.32 (t, J=7.9 Hz, 2 H), 3.62–3.52 (m, 2 H), 3.34 (s, 3 H), 3.11 (t, J=8.1 Hz, 2 H), 1.40 (d, J=7.0 Hz, 3 H); HRMS (CI) calcd for C16H16N3O2Br2Cl (M+H)+: 474.9298; found m/z 474.9285.

Provenance & Evidence