1-[(1S)-1-cyclopropylpropyl]-3,5-dichloro-2(1H)-pyrazinone → HCID 10297912, compound

Participants

Reaction Steps

Prepared in a similar fashion as described for Example 556 using 3,5-dichloro-1-[(1S)-1-cyclopropylpropyl]-2(1H)-pyrazinone and 5-bromo-7-methoxy-3,4-dihydro-2H-1,4-benzoxazine as the starting materials to give an oil. 1H NMR (300 MHz, CDCl3): δ 7.03 (s, 1H), 6.73 (d, J=2.9 Hz, 1H), 6.45 (d, J=2.9 Hz, 1H), 4.44–3.89 (m, 5H), 3.75 (s, 3H), 1.96–1.70 (m, 2H), 1.12–1.00 (m, 1H), 0.92 (t, J=7.3 Hz, 3H), 0.92 (t, J=7.3 Hz, 3H), 0.84–0.72 (m, 1H), 0.56–0.44 (m, 2H), 0.35–0.25 (m, 1H); HRMS (ESI) m/z 454.0518 [(M+H)+, calcd for C19H22N3O3BrCl 454.0533].

Provenance & Evidence