Ethylamine → 5,6-Diphenyl-2-(ethylamino)pyrazine

HRID 1271251노트

반응식

HRID 1271251 반응식
Cl[C:2]1[CH:7]=[N:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[C:4]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:3]=1.[CH2:20]([NH2:22])[CH3:21]>CO>[C:8]1([C:5]2[N:6]=[CH:7][C:2]([NH:22][CH2:20][CH3:21])=[N:3][C:4]=2[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 6341EthylamineHCID 36544935-Chloro-2,3-Diphenylpyrazine

생성물 1

HCID 229319905,6-Diphenyl-2-(ethylamino)pyrazine

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
90 °C

실험 절차

1.00 g of 2-chloro-5,6-diphenylpyrazine was added to 18.7 ml of 2M ethylamine in methanol and the mixture was reacted in a sealed tube at 80° C. for 16 hours. After cooling, 12 ml of a 2M ethylaminemethanol solution was further added, followed by continuous stirring in the sealed tube at 90° C. for 17.5 hours and further stirring at room temperature for 46 hours. After the solvent was evaporated under reduced pressure, the residue was purified by silica gel column chromatography to obtain 531 mg of the desired compound as a pale yellow crystal having a melting point of 121 to 123° C.

후처리

  1. customthe mixture was reacted in a sealed tube at 80° C. for 16 hours
  2. temperatureAfter cooling
  3. addition12 ml of a 2M ethylaminemethanol solution was further added
  4. stirringfurther stirring at room temperature for 46 hours
  5. customAfter the solvent was evaporated under reduced pressure
  6. customthe residue was purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-4d4341bf05be428eba655ca0cc781961
출처 데이터셋
uspto-grants-2007_04
특허 번호
US07205302B2

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