Acetic Acid → HCID 178474498, 화합물

HRID 127126노트

반응식

HRID 127126 반응식
[NH2:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1.[C:8](O)(=[O:10])[CH3:9]>>[C:8]([NH:1][C:2]1[S:3][C:4]([SH:7])=[N:5][N:6]=1)(=[O:10])[CH3:9]

참가 물질

3

반응물 2

HCID 176Acetic AcidHCID 178509208HCID 178509208, 화합물

생성물 1

HCID 178474498HCID 178474498, 화합물

반응 조건

온도
100 °C

실험 절차

Polyphosphoric acid (190 grams) and acetic acid (406 grams) were charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer and heated, with stirring, to 100° C. To this heated, stirred mixture was then added 2-amino-5-mercapto-1,3,4-thiadiazole (250 grams). Stirring was continued for an additional hour at a temperature of 120° C. The reaction mixture was then cooled to 60° C. and poured over ice. A precipitate formed which was filtered and air dried to yield the desired product 2-acetamido-5-mercapto-1,3,4-thiadiazole having a melting point greater than 290° C.

후처리

  1. customfitted with a mechanical stirrer
  2. temperaturethermometer and heated
  3. stirringTo this heated, stirred mixture
  4. stirringStirring
  5. waitwas continued for an additional hour at a temperature of 120° C
  6. temperatureThe reaction mixture was then cooled to 60° C.
  7. additionpoured over ice
  8. customA precipitate formed which
  9. filtrationwas filtered
  10. customair dried

출처 및 근거

ORD 기록
ord-ce039c48b6954b5293366cad7006ac5a
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04255182

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