反应详情

温度

100 °C

Polyphosphoric acid (190 grams) and acetic acid (406 grams) were charged into a glass reaction vessel fitted with a mechanical stirrer and thermometer and heated, with stirring, to 100° C. To this heated, stirred mixture was then added 2-amino-5-mercapto-1,3,4-thiadiazole (250 grams). Stirring was continued for an additional hour at a temperature of 120° C. The reaction mixture was then cooled to 60° C. and poured over ice. A precipitate formed which was filtered and air dried to yield the desired product 2-acetamido-5-mercapto-1,3,4-thiadiazole having a melting point greater than 290° C.

1. customfitted with a mechanical stirrer
2. temperaturethermometer and heated
3. stirringTo this heated, stirred mixture
4. stirringStirring
5. waitwas continued for an additional hour at a temperature of 120° C
6. temperatureThe reaction mixture was then cooled to 60° C.
7. additionpoured over ice
8. customA precipitate formed which
9. filtrationwas filtered
10. customair dried