反应详情

To a solution of 10.00 g of p-toluoyl chloride in 300 ml of dichloromethane, 6.94 g of N,O-dimethylhydroxyamine hydrochloride was added. The reaction solution was ice-cooled and 11.5 ml of pyridine was added dropwise. After the completion of dropwise addition, the mixture was stirred at room temperature for one hour and the solvent was evaporated under reduced pressure. The residue was combined with water, extracted with diethyl ether and then washed in turn with 10% hydrochloric acid, water and an aqueous saturated sodium hydrogen carbonate solution. After drying over anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure to obtain 10.40 g of the desired compound as a colorless oily substance.

1. temperaturecooled
2. additionAfter the completion of dropwise addition
3. customthe solvent was evaporated under reduced pressure
4. extractionextracted with diethyl ether
5. washwashed in turn with 10% hydrochloric acid, water
6. dry with materialAfter drying over anhydrous magnesium sulfate
7. customthe solvent was evaporated under reduced pressure